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KMID : 0882419930450020187
Korean Journal of Medicine
1993 Volume.45 No. 2 p.187 ~ p.193
The Influence of Helicobacer pylori on the Development of Gastric Cancer
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Abstract
ackground : Helicobacter pylori infection is closely associated with chronic active gastritis
and peptic ulcer.
Recently, presence of H. pylori in gastric mucosa could play a role in the pathogenesis
of gastric cancer.
Method : We compared the positivity of CLO test between 41 cases of gastric cancer
group and 54 cases of normal control group according to age and sex.
Results :
1) There was no difference between positivity and negativity according to age and sex.
2) Total concordance rate of CLO test on the normal tissue was 73.2% in the gastric
cancer group, 83.3% in the normal control group, according to the distribution in the stomach.
There was no significant difference between the two groups.
3) Concordance rate between cancer tissue and surounding normal tissue was 91.6% in
upper stomach cancer and 75.8% in lower stomach cancer, total concordance rate was 80.5%.
4) Total concordance rate between cancer tissue and whole stomach was 73.2%.
Conclusion : Our results suggest that Helicobacter pylori could play a significant role in
the development of gastric cancer.
KEYWORD
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